What is Ketamine?

Ketamine has a long-standing and well-studied history as a dissociative anesthetic, and recently as a valid treatment option when addressing mental health conditions such as depression and anxiety —including treatment-resistant varieties, as well as PTSD, OCD, substance use disorder, and suicidal ideation.

It is currently the only clinician-prescribed psychedelic medicine available for use in therapeutic modalities, and is available to the general public in most countries in the world. It has a proven and favorable safety and efficacy profile. Psilocybin is also growing as an accessible medicine in some states and countries like the Netherlands.

Ketamine has been FDA-approved since the early 1970’s as a Schedule 3 controlled substance, while other psychedelic compounds have remained Schedule 1 since their initial classification. This greatly increases the access clinicians have and the ability to study and research the effects of ketamine.  With its dissociative properties being proven beneficial, ketamine’s vast potential as a tool in the treatment of mental health is just starting to be uncovered.

History of Ketamine

Ketamine was first synthesized in 1962 by Calvin Stevens, an Organic Chemistry professor at Wayne State University in Michigan. In 1970 it was approved by the FDA for medical use as a dissociative anesthetic by the US government. It was used mainly to induce and maintain anesthesia in patients undergoing major surgery, due to its pain-relieving and dissociative properties.

Many studies were conducted around the safety, efficacy, and tolerance of ketamine as a dissociative anesthetic, and because it has become a generic drug that is easily affordable for treatment application, ketamine was added to the WHO’s list of essential medicines.

In the early 2000’s, there was more deliberate scientific inquiry and research into ketamine’s antidepressant effects, which were known but not directly explored. These initial studies came back with promising results.

Currently, ketamine is still used as an anesthetic with major benefits of it not impairing respiration, stimulating moderate bronchodilation, increasing heart rate which is important in a setting like shock, and having anti-inflammatory effects. It is also being prescribed off-label by licensed practitioners for mental health conditions such as depression, anxiety, PTSD, OCD, and more.

Legality of Ketamine Treatment

Ketamine is legal for use by registered practitioners, and historically has a high safety profile in surgical and therapeutic use since its synthesis in the 1960’s. Its scope of treatment and potential use-cases continue to grow and develop as ketamine is studied further.

The use of ketamine is regulated, meaning it can only be administered or prescribed by licensed clinicians with the authority and expertise to support its effective use. When used within the context of a surgical procedure or as prescribed by a licensed clinician, it is perfectly legal to use. Any other use of this medicine outside of a clinician’s prescription and directive would be considered illegal.

Ketamine has been approved by the Food and Drug Administration (FDA) for medical use as an anesthetic since 1970.

Ketamine is also available for “off-label” prescription by a licensed clinician. “Off-label” can, understandably, be a confusing term. A common misconception about “off-label” prescribing is that it’s potentially illegal or otherwise untrustworthy.

“Off-label” prescription is when a medicine is used to treat another condition outside of its original medicinal intent as noted by the FDA. Ketamine is currently listed as a Schedule III compound under DEA guidelines. This means it is generally accepted to have medical value for specific purposes, and must be administered by a licensed provider to be distributed effectively.

This is a relatively common practice, with studies showing that one in five prescriptions are given off-label. Fully labeling a medicine for FDA-approved use is a time and cost-prohibitive process, and is typically sought out by pharmaceutical companies looking to apply the medicine for a specific consumer use case.

Generally, when a drug or compound is approved for medical use, it is approved to treat a very specific ailment or serve a very particular purpose. Originally, ketamine was approved for use as a general anesthetic in surgeries that do not require skeletal muscle relaxation. This is an example of “labelled use.”

Fortunately, new science and research is emerging showing that ketamine can be highly effective in treating treatment-resistant depression, anxiety, PTSD, OCD, chronic pain, and a growing list of other applications. In addition to off-label ketamine prescriptions, the FDA recently approved derivatives such as esketamine for treatment of adults with treatment-resistant depression.

For more on ketamine’s legality, you can read our full overview of the legal status of ketamine here.

Is Ketamine Safe?

It has been widely and safely used by anesthesiologists during surgeries involving young children and aging seniors, and those in between.

Ketamine is used in many socio-economic environments due to its relatively low cost, and continues to be used in a clinical setting because it is considered safe, well-tolerated, and effective in what it does.

A factor indicating the safety profile of ketamine as a medicine is that it is used in a variety of medical and therapeutic settings to treat a broad (and growing) number of symptoms and conditions.

Some of these applications include:

  • Anesthesia for surgery
  • Analgesia for a wide variety of painful conditions, medical traumas, or procedures
  • Combating major depression and anxiety symptoms

With the emergence of science that has validated other therapeutic indications for ketamine treatments (depression, anxiety, OCD, PTSD) more and more clinicians have begun to follow the science and treat conditions with off-label prescription of ketamine.

This, along with a paradigm shift in emerging mental health treatments, has helped drive ketamine from the hospital into outpatient clinics, and application through telemedicine. Outpatient clinic models vary greatly and you can receive treatment from anesthesiologists, psychiatric or primary care clinicians, and in some settings, a psychotherapist paired up with a prescriber.

Ketamine does not require the use of expensive or complex medical tools such as external oxygen sources, electricity supplies, or large clinical teams. Simplifying the treatment process helps avoid the possibility of adverse effects through medical or application error.

No medicine available is without risks, potential side effects, and contraindications — symptoms or conditions that an individual may be experiencing that indicate treatment may not be suitable. This is why ketamine is a regulated medicine, used in structured procedures and administered by medical professionals.

Some of the contraindications include:

  • Uncontrolled high blood pressure or glaucoma, increased intracranial pressure, or heart problems.
  • Pregnant or breastfeeding woman
  • Thyrotoxicosis (excess thyroid hormone)
  • Psychosis and active mania with or without psychosis

As with any compound, it’s easiest to consider this in terms of the half-life of ketamine. A half-life is how long it takes for 50% of the compound to be excreted from the body.Ketamine metabolizes quickly in the body, with a half-life of around 2.5 hours. This means that after 2.5 hours, 50% of the ketamine has been excreted from the bloodstream. For comparison, coffee has a half-life of five hours. Given this, after about 10-12 hours since the initial dosing, a majority of the ketamine is out of your system. This is independent of the subjective experience, which subsides after about an hour.

Ketamine’s metabolites can remain in the body for almost two weeks, metabolites are smaller by-product molecules from the metabolic process, or the process of breaking down larger molecules for use or processing in the body.

Overall, this is one of the advantages to work with ketamine: it’s very well tolerated across a large population, it has a fast onset and manageable total duration, and is metabolized and processed through the body quickly as well.

Given the range of patients that receive it in medical and therapeutic settings, and research supporting the efficacy of its mental health treatment modality, ketamine is considered a safe and well-tolerated medicine.

Neuroscience of Ketamine

Depending on which clinical context ketamine is applied in — the anesthetic or psychiatric — its effects on the brain and neurological pathways differ.

Glutamate production and BDNF

At lower doses shown to have an antidepressant effect, ketamine appears to increase the release of glutamate, a neurotransmitter. The ketamine then preferentially blocks glutamate at the NMDA receptors but doesn’t block glutamate binding to adjacent AMPA receptors. The net effect is to increase AMPA activation. The effect is magnified by the way ketamine induces the neuron to make additional AMPA receptors.

By increasing the level of glutamate transmission and shifting its balance of activation from NMDA to AMPA receptors, ketamine increases production and release of BDNF (brain-derived neurotrophic factor). Referred to as “fertilizer for the brain,” BDNF is a protein that helps promote the growth, maintenance, and survival of neurons, enhancing neuroplasticity.

The mTOR pathway

Ketamine also stimulates a cell pathway called mTOR (mammalian target of rapamycin), which regulates many processes involved in cell growth, including synthesizing the proteins needed for long-term memory. In combination with increased BDNF production, mTOR stimulation improves connectivity in the prefrontal cortex and hippocampus, key areas of the brain associated with emotional regulation, increased synaptic plasticity, and the potential to reverse the synaptic damage that occurs in these areas when the brain is subjected to chronic stress.

Due to these neuroplastic effects, regrowth of synaptic transmitters can happen within a few hours of a sub-anesthetic ketamine dose. When the atrophied neurons can repair the damage and regrow their connections with other neurons, symptoms of depression and anxiety improve.

Cell structures and other neurotransmitters

Another possible mechanism for ketamine is its action on structures within the neuron. Some studies suggest that ketamine accumulates in lysosomes (organelles that contain digestive enzymes) and synaptic vesicles, which might then trigger mTOR signaling. Ketamine can also trigger increased release of dopamine and noradrenaline. Research related to these mechanisms is complex, with more being uncovered as it advances.

Neuroscience of Depression

The impacts of stress and depression on the brain aren’t just at the molecular and cellular level. Depression impacts connectivity at the brain macro level as well. By using functional magnetic resonance imaging (fMRI), researchers have been able to see how people with depression seem to have weaker connections within larger neural networks, which can be seen in the prefrontal cortex.

The prefrontal cortex is the seat of higher-level cognitive processes, including executive function —the ability to control short-term behaviors in favor of self-control, planning, decision-making, problem-solving, and long-term goals. When the subregions of the prefrontal cortex aren’t communicating well, as is the case in depression, executive function can be dysfunctional. Ketamine seems to help improve global connectivity in this portion of the brain and improve the linkages among the subregions.

Psychological Basis of Ketamine

Ketamine use in the treatment of mental health conditions is still an emerging area of research and study. More trials are underway to demonstrate the depth and breadth of ketamine’s applications and potential.

There are multiple core areas of research that have already been published:

  • Ketamine as a treatment for major depressive disorder (MDD) / treatment-resistant depression
  • Ketamine as a novel treatment for general anxiety and social anxiety disorders
  • Using ketamine to manage bipolar disorder (BPD), obsessive-compulsive disorder (OCD), and substance use disorders (SUD)
  • Ketamine as a treatment for managing suicidal ideation

As more studies emerge, the results are promising: From the rapid onset of results, to long-lasting effects, ketamine as a novel treatment in the mental health space is showing to be highly effective.

There are a number of features that make ketamine therapy remarkable and effective as a medicine for the mental health field.

Rapid onset and visibility of results and positive outcomes  

Unlike some traditional pharmacological interventions such as SSRIs (selective serotonin reuptake inhibitors), which can take up to 6 weeks to begin showing desired outcomes, some clients working with ketamine therapy report seeing results within hours of their first treatment.

Long-tail endurance and durability of its outcomes

The second core benefit is what is called the durability of the benefits — those that extend beyond just the dosing session or the immediate hours following administration.

Early research has highlighted enduring effects from a single treatment that remain noticeable weeks after the dosing session.

Addresses and heals underlying drivers of the conditions

Along with the immediate mood-regulating effects of a ketamine session, there may be longer-term neurochemical and biological benefits from ketamine.

Some of these benefits may include increasing the presence of brain-derived neurotrophic factor (BDNF) in the brain, which can help create new, healthy neural connections.

The dissociative and psychedelic subjective experiences ketamine induces can provide new behavioral insights, clarity into life circumstances, and surface deep-embodied emotions or feelings. Integrating and addressing what comes up in ketamine therapy can lead to more resiliency, positive affect, and brighter futures for clients.

It fits into your life

Convenience is an important factor that makes ketamine therapy a useful and appealing treatment option.  The experience itself lasts around 60-90 minutes when using sublingual tablets, so it’s not a full-day commitment for those whose schedules don’t allow.

Because ketamine’s benefits and durability can be long-lasting, you aren’t required to take a pill every day to see benefits.

Any side-effects are often minimal and subside quickly

With programs like Mindbloom, you can receive psychedelic therapy from the comfort of your own home, monitored by a close friend or loved one, while under the guidance of experienced clinicians and highly-trained guides.

The “felt” or physiological effects can last 1-3 hours (physical effects can still be felt after the session), and short term side effects such as altered sense of time, nausea, restlessness, and elevated blood pressure or heart rate typically subside shortly following the treatment experience.

With a relatively proven and promising efficacy profile for mental health treatment, coupled with the flexibility and adaptability of the treatment programs themselves, ketamine therapy can be a life-changing experience that doesn’t require you changing your life for it. It meets you where you’re at.

Alongside its dissociative properties, at certain doses ketamine can also induce novel subjective experiences or classic psychedelic phenomenology. This sense of experience or journey can provide important insights and felt experiences that can help us manage depression in the short and long-term.

“A ketamine psychedelic experience tends to offer up the possibility for transformation of the self by isolating the mind to some extent from external sensations, altering body consciousness toward an experience of being energy without form, and by amplifying and scrambling the contents of mind in unpredictable ways—all of this generating the potentiality for changes in consciousness that may be beneficial and persistent. Coming back from a ketamine journey as a somewhat different being is quite predictable.” Wolfson M.D., Phil. The Ketamine Papers: Science, Therapy, and Transformation (p. 646). Multidisciplinary Association for Psychedelic Studies. Kindle Edition.

Here are some of the positive phenomenological healing effects that can come through ketamine therapy:

  • Emotional Regulation: An increased ability to understand and interact with emotions.
  • Cognitive Distance: Feeling more ‘space’ or ‘distance’ between external events and an individual’s reaction to them. This allows for more intentional behavioral responses, the rewriting of automatic triggers, and deeper introspection.
  • Embodied Feelings: Visceral emotions and feelings returning to the body, potentially some that may have been discarded or forgotten (joy in a depressed person, for example).
  • Novel Insights: Ketamine can facilitate crucial insights that when integrated, can provide powerful and significant changes to how the individual views themselves and the world around them.
  • New Experiences: New experiences or states of consciousness can provide motivation, inspiration, or understanding of the next steps. This helps to clarify meaning and purpose and catalyze improvements to mood, emotions, and physical experience.

Effects of Ketamine

It’s important to distinguish the two ways in which ketamine treatments provide therapeutic value, as this will help you make a decision as to which one is right for you, and when.

The Biological Effects of Ketamine

There are the neurobiological effects and benefits when receiving ketamine. Through these effects, we would expect a general improvement in overall mood, an increase in brain-derived neurotrophic factor (BDNF), and bolstering of neurons that have been worn down over time by the body’s physiological response to things like anxiety and depression.

The biological effects are dose-dependent, and happen regardless of an individual’s subjective experience with the medicine.

Learn more about the neuroscience of ketamine here.

The Subjective Effects of Ketamine

There are also subjective or phenomenological healing effects that ketamine can provide depending on the dose. These effects include novel ways of thinking, disconnection from thoughts or emotions, dilation of time or space, out-of-body experiences, and more. These experiences vary between each individual and each treatment, but can be essential catalysts for deep transformation when treating mental health conditions such as depression or anxiety with ketamine.

The subjective effects have a ‘sweet spot.’ They need a certain dosage to surface, and can be overtaken by the dissociative or sedative effects at higher doses.

This ideal range for the subjective or phenomenological effects of ketamine is an important point to consider when looking at methods of treatment, and the results you want to achieve. An experienced clinician can help you make the right choice in this regard.

A 2019 study on individuals with major depressive disorder demonstrates the potential for longer-term positive effects:

“There was a significant improvement in depression, anxiety, and the severity of illness after 2 weeks and 1 month of the last dose of ketamine. Significant improvement at 1st [hour] of the first dose was seen in depression and anxiety and not for illness severity. There were transient adverse effects observed in some patients which subsided within 1 [hour].”

Where to Find Ketamine Treatment?

Using ketamine as part of your healing process is legal in many states and countries around the world. As it is a scheduled and regulated substance in most countries, you will need to find and work with a licensed clinician or practitioner who is able to prescribe and work with ketamine as part of their practice.

Depending on the method of administration you’d prefer, this will influence available clinics and/or practitioners you have access to. For intravenous (IV) or intramuscular (IM) ketamine application, you will need to find a clinic that has the capacity to work with this. Similarly for intranasal spray, you will need to find a practitioner who works with this method of administration.

If you are in the US, you are able to work with sublingual RDT’s (rapid dissolving tablets) through Mindbloom from your own home. Mindlboom currently provides virtual care in 11 states.

You can also search through practitioner forums, clinic listings, or take a look on Google to see if there are any practitioners or clinics in your areas.

How to Take Ketamine

While ketamine infusions and injections are the most common method of delivery used in mental health treatments, there are a range of options. Here’s a quick overview of the different methods one can expect when working with ketamine.

Sublingual Tablets or Troches

Tablets or troches (pronounced “tro-keys”) are compounded tablets from a pharmacy that are absorbed into the brain/bloodstream sublingually, or held in the mouth. Dosing can vary from 10-200 milligrams (mg) per tablet on average, depending on the compounding pharmacy and the order from the clinician.

Tablets are the method utilized by Mindbloom clinicians, allowing for a greater flexibility in treatment based on the client’s response to the medication. Tablets also provide powerful experiences, but without the risk of infections or introducing harmful agents into the bloodstream — contributing to an increased safety profile.

IV Infusion or IM Injection

Intravenous (IV) infusions or Intramuscular (IM) ketamine injections have similar effects. The difference is that IV is typically infused into a vein with a bag that drips the substance in while IM is injected directly into a muscle in the arm with a needle.

Nasal Spray

Ketamine nasal sprays are a synthesized mist stored in a spray bottle that is applied according to the delivery timeline outlined by the clinician. This is the latest delivery method to gain FDA approval with the introduction of Spravato. Spravato is Esketamine which is the S-form of ketamine. Esketamine is FDA approved for treatment resistant depression through nasal administration, while the use of Ketamine in any form is off-label.

The bioavailability and desired effect (sub dissociative, sub psychedelic, anesthetic) of each delivery method, which is the proportion of the compound that enters the body’s circulation, is what determines the typical dosing ranges.

Eligibility for Ketamine Treatment

Right now, ketamine therapy is the only legal avenue (not including clinical research trials) for someone to receive psychedelic therapy. Common reasons to seek this treatment are to help work through depression and anxiety.

When considering treatment options, whether psychological, or pharmacological, there can be contraindications to consider. Contraindications are specific circumstances that could make someone ineligible to move forward with the treatment.

Ketamine, due to some of its effects both physically and psychologically — has its own set of contraindications. All medical considerations are discussed in your consultation with a licensed clinician.

If you’d like to check your eligibility, you can try our survey here.

The Future of Ketamine Treatment

This is where the current state of ketamine treatments and psychedelic therapy programs are. As this world continues to grow and expand through research and awareness, new avenues may open up. New treatment modalities, such as the recent introduction and legalization of Spravato nasal spray — will increase access and awareness for ketamine treatment, and this page will update to reflect ongoing developments in this world.

If you have any other questions, or would like to know more about the world of ketamine treatments and psychedelic therapy, feel free to explore our additional free resources/information.

If you feel called to work with the medicine and experience it for yourself, feel free to reach out and let our team know.

Contraindication is a term that arises throughout the course of psychedelic therapy a fair bit, particularly during the intake process, and for good reason. Over and above individual healing and client outcomes, client safety is always the number one priority of a trained practitioner.

These experiences are designed to facilitate healing, and it is counterproductive to embark on a healing journey that has the potential to do more harm than good. Contraindications are one of the ways that practitioners ensure client safety, and make sure that the right people are embarking on experiences best suited for them, their circumstances, and their healing goals.

Defining Contraindication

A contraindication is any specific drug, procedure, or medical condition that demonstrates that it is not safe or advised for a particular individual to move forward with a particular treatment. In other words, they are warning signs that if an individual has a contraindication for a particular medical treatment, it is inadvisable, and potentially dangerous, if they continue moving forward with that treatment.

There are two levels of contraindication: relative and absolute.

Relative contraindication

A relative contraindication means that the client and care team should exercise caution when moving forward with the protocols of choice, as the potential exists for some negative interaction.

Combining certain types of medications, for example, can be a relative contraindication. If the individual and care team feel that the benefits most likely will outweigh the potential risk, then they can move forward with the treatment plan.

Absolute contraindication

An absolute contraindication means that the client and care team should not move forward with the potential treatment protocol as it is likely this will cause more harm than good, and in some cases can be life-threatening.

An absolute contraindication should be a hard stop for individuals and care teams if they become aware that a serious contraindication exists.

Psychological and physiological contraindications

Though contraindications are often noted as a complete group, you can further segment these by psychological contraindications, and physiological contraindications.

Psychological Contraindications

These are contraindications relating to the individuals mental state and overall psychological health. Examples of potential psychological contraindications can include things such as suicidal ideation, schizophrenia, or active mania or hypomania as seen in bi-polar personality disorder.

Physiological Contraindications

These are contraindications relating to the individual’s biology and physical state. Examples of potential physiological contraindications can include medical history such as high blood pressure, abnormal heart rate, certain kinds of medications, pregnancy, or glaucoma.

Honouring contraindications is done for two specific reasons: to prevent and mitigate both short-term acute, and long-term enduring adverse events or reactions to the experiences. There can be acute impacts such as bodily discomfort, nausea, abnormal heart/breathing rates, or fainting/death. These also help mitigate long-term adverse reactions such as depersonalization, manic or psychotic, depression and/or suicidal behaviour, etc.

Fortunately, if practitioners honor and respect the specific contraindications for each medication and experience, psychedelic medicines and psychedelic therapy can be well-tolerated, safe, and effective experiences for healing. If a person is physically and mentally able to receive the medicine, these experiences have only a minor body load, and hopefully do more healing than harm for whatever it is the individual is working through.

As always, whenever you are in doubt or would like a second opinion, share openly and honestly with your care team, and seek second opinions so that you are making the best decisions for your health and your healing journey.

Body Load and the LD50

On the whole, most compounds used in psychedelic therapy do not have an extreme body load —the overall impact directly on the body, when compared to other recreational drugs or certain medications.

There are many other compounds, such as alcohol, tobacco, caffeine, or some pharmaceutical medications that have a much more direct and pronounced effect on the body. These effects can lead to illness, debilitation, or death if ingested in too great amounts too quickly.

A reference point here is what is known as the LD-50: the amount of the compound that would serve as a lethal dose for 50% of the general population. Many classical psychedelics (psilocybin, LSD) have very high LD-50’s and it would prove very difficult for an individual to reach a physically lethal dose. In comparison, caffeine and nicotine are much more acute and have lower LD-50’s.

Although the compounds themselves are often handled reasonably well by a large portion of individuals, this is not the only basis for a contraindication. As psychedelic compounds work on the mind as well as the body, it is important to take this full picture into consideration. There are some physiological concerns, particularly around heart rate, and blood pressure alongside contraindications concerning mental health.

Psychedelic Therapy Contraindications

Psychedelic therapy can be healing for individuals, but it can also be challenging for some and end up causing more harm than healing. This is why the medical screening and intake process is so important, so that you arrive at safe and effective healing protocols for each individual. A major part of the medical screening process is to look for contraindications.

As psychedelic therapy involves the use of certain medicinal compounds, there are both psychological and physiological contraindications that must be screened out. These contraindications can cause serious long-term damage if not acknowledged before going into a psychedelic experience.

This list is not exhaustive and should not be taken as medical advice, always seek the input of a trained and licensed practitioner before working with these experiences.

Examples of possible psychological contraindications for psychedelic therapy include:

  • Personal history of schizophrenia, bipolar disorder, or severe depression
  • Family medical history of schizophrenia, bipolar disorder, or severe depression
  • Active suicidal ideation or previous attempts
  • Major emotional dysregulation

Examples of possible physiological contraindications for psychedelic therapy include:

  • Actively taking certain medications like SSRI or MAOI, and the specific dosages
  • Very high or very low blood pressure
  • Heart arrhythmia or irregular heart beat
  • Personal or family history of epilepsy/seizures

It is important to discuss these contraindications with your practitioners and care team, so that everyone is fully aware of the situation, and that the best plan of care can be made for each individual. Some practitioners and therapeutic experiences are better able to handle particular instances, and a personalized program can be created to serve these unique cases.

Ketamine Therapy Contraindications

Much like any other medical compound and psychedelic medicine, ketamine has its own list of associated contraindications that are important to honor to ensure client safety. There are many similarities with the previous psychedelic therapy contraindication list, and a few other considerations given the mechanisms of action and the particular body load that comes with ketamine ingestion.

Possible psychological contraindications of ketamine include:

  • Personal or family history of schizophrenia, manic and hypomanic bi-polar disorder
  • Active suicidal ideation, previous attempts
  • Psychosis and major emotional disregulation

Physiological contraindications of ketamine include:

  • Very low or high heart rate
  • Very low or high blood pressure
  • Personal/family history of epilepsy/seizures

What If I Am Contraindicated?

You may be reading this and notice that there may be a point or two here that could apply to you. This is alright, getting appropriate information is always the first step.

If you believe that you may be contraindicated for psychedelic therapy or ketamine treatment, it’s always important to speak to your primary care provider and with the practitioners / clinicians administering the medicine / experience. This is not something that you can or should try to determine on your own. Work alongside the trained and experienced practitioners that are here to support you and provide the best possible healing protocols for your growth and wellbeing.

If you think you have a contraindication, you can do the following:

Contact your practitioner and tell them

Safety is always the number one priority. Specific contraindications exist to ensure your safety and prevent further harm from these treatments. They should not be taken lightly or overlooked. If you have any concerns or questions, contact your care team and open a discussion.

Share all relevant information

All information is helpful, it is never a bad idea to share as much as possible with your care team. It helps them to make the most informed and effective decisions possible. Some practitioners are more comfortable working with certain symptoms than others, so giving them the full picture will be helpful.

Address them with care

As mentioned above, some contraindications may only be relative contraindications, meaning you and your care team can make an informed decision, look at all the options, and make a decision to move forward.

Some contraindications can be managed or mitigated, such as working with your care team to wean off of SSRI medication if they are contraindicated. Never do this by yourself, always do this under the supervision of clinical staff. However, you can work with your practitioners to effectively manage and mitigate any relative contraindications. If they are absolute contraindications, see the next section.

Find the appropriate medicine

If you have an absolute contraindication for a certain medicine or type of experience, that just means that this avenue may not be best suited for you at this time.

Despite a potential interest in psychedelic therapy, doing this work with a contraindication can severely aggravate the condition, or do much more harm than good. Working with trained professionals to find the experience that is suited for you will do far greater than trying to force your way into a potentially dangerous situation.

Differences in Medicines/Experiences

This is a broad overview and introduction into contraindications found in psychedelic therapy and ketamine treatment. It is not possible to summarize all the contraindications for all medicines, as some medicines are able to work with contraindications that others are not.

For example, ketamine works on a different system in the brain, working with the glutamate instead of the serotonergic system. As a result, it is better able to work with clients actively taking SSRI medications.

Each medicine and each therapeutic experience will come with its own personal list of contraindications, so if you are contraindicated for one medicine, you may be able to find other medicines or other experiences that are better able to serve those specific symptoms.

Whenever you are considering any form of new experience that works on your mind and body, from meditation, to breathwork, to psychedelic therapy,  it’s important to look up the associated contraindications. Yes, even contemplative or embodied practices such as yoga, meditation, and breathwork have specific contraindications.

Conclusion

Contraindications are established and response protocols for them are enacted for client safety, to ensure that these remain spaces and experiences for healing and not for harm. They are not to be taken lightly, and you should work alongside trained professionals to help determine the best course of action for yourself.

However, by sharing any questions or concerns, by consulting the trained experts you are working with, you can determine the best course of action for you, personalize your programs so they fit with your unique circumstances, and move forward on your journey of healing and wholeness.

Whether you’re in the process of deciding to embark on a journey of healing with psychedelic therapy, or are currently moving through a therapeutic protocol, you may find yourself in situations where you want to explain the process in more detail. Perhaps a friend is asking you, a family member is inquiring, or you’re trying to explain the process to a colleague at work.

Whatever the reason may be, it’s not always easy to put your experiences, intentions, outcomes, or aims into words —and it’s not always necessary to do so. This piece explores the process of explaining psychedelic therapy in general, and your unique experiences, to others who may be asking or are interested.

Do I Need to Share My Story?

To begin, it’s important to address whether or not you need to share your experiences or reasons for treatment at all.

The decision to enter any therapeutic program is a personal one. It is a decision made by yourself, for yourself. First and foremost, this experience is for you, your healing, and your wholeness. If there is any aspect of sharing that you feel moves you away from the healing process, honor that feeling and instead choose to keep your stories your own.

There is a reason for this: we are social creatures. We react to and value the opinions of others, it’s a built-in response mechanism. If you have a transformative experience or an important moment throughout your program, it is not received as you may have expected or wished when sharing, the other person’s reaction to this news can impact you.

As you can be in a sensitive integration window while sharing this news, these reactions can remove some personal enthusiasm about the experiences, foster doubt in the significance of the experience, or have you question the benefits you received. It’s not a guarantee that this will happen. Sometimes sharing your story can be highly generative, where you benefit greatly from sharing. However, this is something worth considering before sharing the personal details of your experiences.

You don’t owe anyone an explanation, and if you don’t feel comfortable sharing something, you can simply draw a boundary and say that you’d like to keep that information private or don’t feel like sharing at that time. You can also communicate that perhaps at another time in the future would be better for you.

This is individual work, and the decision to share or not is your individual choice. It should be made with your best interest in mind.

On the other hand, it is relatively common that after a significant experience in a session or during the integration period, a motivation to share this experience with others can arise. You may have experienced a great benefit from this work, and would like to give others the awareness and the opportunity so that they might also benefit from the experience.

This is well-intentioned, and it’s helpful to ensure you provide relevant, accurate, and contextual information so that all individuals can make informed, effective decisions for their own healing processes.

Talking with Different “Stakeholders”

Just as with any interpersonal dynamics, you will likely have varying levels of relationships you wish to share more with. This could be: an intimate partner, close family members, interested friends, or inquisitive colleagues, or even sharing online in discussion groups.

These “expanding circles of care” can, and often do receive varying levels of openness and vulnerability from people. You share the most with the people you are closest with, and share more broad or general overviews with those who are further removed from your day-to-day life.

Relationship or close partners

Your partner may know a fair bit about this process, or they may not and this is something you’d like to bring up.

When sharing, it’s helpful to stick to what is true for you. What is true in your life that makes you interested in embarking on this healing journey? What did you experience that was beneficial or significant for you? No one can deny the truth of your own experience, and it is simply reporting or sharing what happened.

It can be helpful to share with your partner, at least at a high level, so that you can be supported throughout the process. Although this is individual work, you are not alone in this process, and having a robust support system around you throughout the process can be highly generative for your overall experience and outcomes, and this can start with a trusted partner.

Family members

Depending on your relationship with your family, this first circle of proxy is yours to decide how much you wish to share. If you’d like, you can say you’re embarking on a therapeutic experience, designed to help you reconnect with yourself and with the world, to become a more whole individual for those you care about.

You are working with experts, in structured experiences, to help unlock and unblock parts of yourself. If you’d like their support or understanding, you can choose to share more about the clinical or guided nature of the experience. If not, you don’t need to share anything you are not comfortable with.

As always, having a support network around you throughout this process can be helpful, but only if you find personal value in it.

Friends

Friends are often individuals that genuinely enjoy your presence and care about your wellbeing. If you are excited about this new healing journey, you can share with them. Oftentimes, some clients may notice that friends or family start to notice small or large shifts in personality, mood, or ways of acting. They may inquire as to what has brought this about, and you can share at whatever level you’re comfortable with.

You can say you’ve been doing some work on yourself, that you’re working in a new therapeutic model, or that you are moving through a psychedelic therapy protocol with a practitioner and a particular compound.

An important note here is just because you have shared some information, that does not obligate you to share everything. If at any point you feel uncomfortable, or don’t feel you have an adequate answer, you can simply decline to share further. Your friends are a support system, and they should honor that request.

Primary care providers

A core relationship that you may want to discuss psychedelic therapy with is your primary care provider, your family doctor, therapist, or relevant medical professionals. Some providers are receptive to augmenting your care with psychedelic therapy, while others may not have a definitive opinion on it, and others may be firmly against it.

First and foremost, it’s very helpful to bring this conversation to the surface. This is a new development that impacts your health and wellbeing, and it’s helpful for your primary care provider to have complete information so that they can also help make the best decisions for your ongoing healing and health.

If they have questions or concerns, pointing them to the current science, and explaining your rationale for starting this program are good starting points. However, this is not something you need to tackle yourself, and you can ask your psychedelic therapy practitioner to contact your primary care provider so that all parties can come to an agreement, understanding, and make the best decisions possible.

Acquaintances / general public

Regarding the broader public, it’s less likely that you are asked directly about your experience from someone, and more likely that you are excited or interested in sharing information publicly about your own experience. Here, it’s important to honor the experience, communicate contraindications, and the right contexts for individuals to embark on this work.

Despite some common parlance, psychedelic therapy is not a panacea or “magic pill” experience, and some individuals are not suited for psychedelic therapy. It’s important to remember these points as you go out and plan on sharing your experiences publicly.

Following the science, citing your sources, respecting the differences in people are all important notes to remember when beginning to share more publicly about your process and experiences.

Common Questions & Responses around Psychedelic Therapy

Is this psychotherapy?

This depends on the specific program you are working within. There are psychedelic-assisted psychotherapeutic programs that exist, where you work alongside a therapist in familiar talk therapy dynamics. The difference being that you’re being assisted by psychedelic medication to surface important insights or catalyze novel emotional states. If you are working in one of these programs, yes, this would qualify as traditional therapy.

Most often, the answer would likely point to the idea that these experiences are inherently therapeutic. They provide the structure and experiences that are beneficial in helping you understand more about yourself, heal disparate parts of yourself, and cultivate a deeper relationship with yourself, others, and the world around you. Some experiences, such as individual sessions, are not specifically therapy as they do not involve talk sessions with a licensed therapist, though they can absolutely provide therapeutic outcomes and benefits.

Many psychedelic therapy protocols and programs involve the combination of psychedelic medicine sessions, and interactions and discussions with trained clinicians, facilitators, guides, or practitioners.

Why are you doing this?

This is a highly personal question, and it’s up to you to determine the level and depth of information you are comfortable disclosing. Once again, this is your process, and you should not feel obligated to share anything. This is a personal decision and it can remain personal.

If you would like to share more, you can allude to the fact that you are working through some things personally, and have found a safe and effective method to help with that process.

You can mention it’s to augment and assist the existing personal and therapeutic work you’re already doing, or simply that you had found some supportive science around the experience and wanted to see if it could be beneficial for you.

What are the effects?

This is another question where it is at your discretion to disclose what you are comfortable with.

Sometimes this question can refer to what effects and/or benefits you have noticed in yourself personally. Other times, it can be a question to learn more about the potential effects of psychedelic therapy in general. It can be helpful to confirm the intent of the question if there is any confusion. If you’re not comfortable sharing your personal story, you can default to sharing some of the common effects and benefits that clients may see throughout a program.

Some potential effects and/or benefits of psychedelic therapy can include:

  • Deeper sense of self-acceptance, self-love, self-image
  • Improvement in baseline mood, reduced depressive / anxious symptoms
  • Novel insights, emotions, thoughts, feelings
  • Space to process and heal old trauma, habitual patterns, ways of behaving
  • Working through addictions or addictive tendencies

Is this safe / effective / legal / well tolerated?

It’s important to keep in mind that these answers will vary based on two main factors: the medicine that you are working with, and the specific program that you are embarking on.

Questions around safety, tolerability, and legality, these answers vary depending on the compound and the programming surrounding the experiences.

Safety

You can refer those inquiring to our article on ketamine safety for more information on the specifics of ketamine treatment. Also, you can refer to ketamine’s contraindications to demonstrate that if you are not contraindicated, psychedelic medicines themselves are well received and safe in the majority of individuals.

Effective

Psychedelic therapy has been growing in awareness and interest the past few years specifically due to its efficacy in treating a number of mental health conditions, including previously treatment-resistant cases. For a growing number of individuals and specific conditions like depression and anxiety, psychedelic therapy is proving highly effective in helping individuals on their journeys towards healing and wholeness.

Tolerability

Depending on the particular compound, psychedelic medicines are largely well-tolerated in healthy individuals. There are certainly contraindications —specific markers that would make someone ineligible or not recommended to use psychedelic therapy— but without those contraindications, psychedelic medicines are largely well-processed by the body with manageable side-effects in the short and long-term.

Legality

At the time of publication, ketamine is currently the only legal psychedelic medicine available to the general public. There are a number of other compounds and medicines moving through various stages of the approval process, though these are only available in academic or clinical studies at the time. If you are working with ketamine treatment in North America, or are in a country where the laws allow for, or are enrolled in a clinical study, these experiences are legal under clinical supervision.

Honoring Yourself and Your Process

If you do decide to share some of your story, some of the process, or a deeper look at psychedelic therapy protocols, here’s a gentle reminder on how these messages may be received.

Depending on an individual’s unique viewpoints, they may be doubtful, express concerns, question psychedelic therapy’s legitimacy, or they may not react in any major way. All of these are okay.

These reactions are not a reflection on you or your process, and it’s important to return to your direct experience, the feelings and outcomes you realized during your treatments. The validity of your experience is never in question, even in the face of doubt or concern from someone.

These can be grounds for fruitful conversation, but you do not need to “sell” anyone on the benefits. Your experience cannot be invalidated, and these experiences are not meant for all individuals. Overall, exercise discernment and personal sovereignty when opening and sharing your experiences with others.

Scientific Validation

There may be some well-intentioned individuals who become curious or passionate about what you’re doing and would like to explore this for themselves. You’re welcome to share any results, scientific validation and research, or any supporting points concerning psychedelic therapy.

Fortunately, there has been a host of studies over the decades within psychedelic therapy and ketamine treatment that point to the potential of these experiences and medicines to be catalysts and aids in mental health treatment and healing.

There are a host of resources on the Mindbloom website regarding ketamine treatment, including resources on the neuroscience of ketamine, various clinical studies, and explorations into ketamines ability to aid anxiety and depression, and direct stories from clients who have completed the program.

There are various universities and institutes who are spearheading ongoing research on the efficacy and potential of psychedelic therapy, in everything from inducing mystical experiences, smoking cessation, managing depression & anxiety, and many other symptoms.

These can serve as resources you can provide, and also become a gentle reminder that the academic and clinical worlds are now able to begin much deeper study into the use and outcomes of these experiences, and more science continues to emerge.

Conclusion

Psychedelic therapy can be transformative in individuals’ lives. Whether it’s sharing stories publicly, or being asked or sharing directly with people in your life, it’s important to honor your own process, to follow the science and what it demonstrates, and to exercise your own boundaries and discernment.

Your work in this field is beautiful and individual, you are not obligated to share, though it can be very beneficial to have a support system and to open up to others who you care about. With a balanced approach, and with an open heart, you can begin to open up these conversations to more people, and bring psychedelic therapy to those who stand to benefit from it.

Psychedelic therapy and the psychedelic experience are entering a period of renewed individual and collective interest, most notably for the initial evidence pointing to their ability to catalyze individual healing and transformative processes.

As interest and public awareness of these experiences grow, naturally a curiosity arises to learn more about what the psychedelic experience is, and how it serves as this catalyst for inner transformation. But how do you define a psychedelic experience? Are there classic hallmarks that are common across a wide spectrum of individual experiences?

Although all experiences are different, each individual will have their own unique experience when working with psychedelics or within psychedelic therapy, and each experience itself will be unique for that person. There are a few consistent hallmarks, or defining character traits, that we can point to that provide a general overview of what the psychedelic experience is and what it can do.

Defining a Psychedelic Experience

Let’s begin with a simple definition of terms. The term “psychedelic” was originally coined by English psychiatrist Humphry Osmond in a letter addressed to Aldous Huxley back in the 1950’s.

It is a combination of the Greek words “psyche” (mind) and “delos” (to reveal). This gives us the common definition of psychedelic as “mind-manifesting”. Clinically, psychedelic refers to a class of compounds that reliably induce this state in individuals at certain dosages.

When combined, the psychedelic experience is a direct, embodied experience of how an individual’s mind works. This sets the foundation for the deeply introspective potential that these compounds and experiences have to offer individuals.

Psychedelic experiences often provide individuals unique insight, emotions, or experiences of why and how they are the way that they are. They discover where patterns of behaviors emerge from, how they relate to themselves, others, and the world, and the current state of who they are at the time of the experience.

Factors of a Psychedelic Experience

There are a number of common traits, or hallmark characteristics, of a psychedelic experience. Psychedelics are often also said to be able to induce a “mystical experience” —a profound experience with a number of unique qualities not often afforded in day-to-day waking life.

It is important to note that for several decades there has been an interest in officially defining a universal taxonomy of characteristics of the psychedelic experience, but there is no currently universally accepted taxonomy to date. These are simply common traits and generally accepted definitions from those across academic disciplines.

Factors of a Mystical Experience

William James, a prominent American Psychologist, is often credited at having compiled a robust overlook at the hallmarks of a mystical experience, many of which apply to the classic traits of a psychedelic experience. These are:

  1. Ineffability: A sense of being unable to effectively or adequately put the experience into words or language. A sense of the experience being “beyond language”, something that cannot be described in words, but rather must be directly experienced at the level of the individual.
  2. Noetic Quality: The sense that the experience provides insight or access to information or sensations that were previously inaccessible at the level of normal, waking consciousness.
  3. Transiency: The fact that these experiences are often fleeting, and are not often sustained for more than a few minutes or hours at the most.
  4. Passivity: The distinct sense that the mystical or psychedelic experiences happen to an individual, that it is outside the realm of direct control or influence by the individual.
  5. Unity of Opposites: A feeling of wholeness, the reconciliation of paradoxes or opposites. A felt sense that everything both internal and external to the individual is part of a greater whole.
  6. Timelessness: An experience of being beyond time, outside of the confines of the linear progression of time in a realm that is realm, but not bound by limitations of time or space as it is commonly understood.
  7. The True “Self”: A distinct sense that the experience unfolding here is extremely real, that the “Self” you see is perhaps a more “real” or “true” Self than normal waking consciousness.

These seven hallmarks of a mystical experience are commonly included in the understanding of a psychedelic experience, and you will notice many similarities here, with a few variations or alternative manifestations, in the classic markers of a psychedelic experience.

Factors of a Psychedelic Experience

There are several similarities in psychedelic experiences and mystical experiences, as part of what provides the profundity of psychedelic experiences is that they can induce mystical experiences in individuals.

  1. Ineffability: A common overlap between the mystical and the psychedelic is that they both appear to be beyond language as an adequate description. It is challenging to encapsulate the totality of the experience into language and phrasing.
  2. Novel Experiences/Insights: The psychedelic experience can provide or induce novel experiences, emotions, insights, revelations, or connections that were not previously known, understood, or embodied as reality.
  3. Ego Dissolution: A distinct trait of the psychedelic experience is the dissolution of the sense of being an isolate, separate Self, an ego.
  4. Timelessness: Another overlap with the mystical experiences, psychedelic experience can often bring about a sense of timelessness, that the experience is taking place outside of time.
  5. Higher Order Reality: A sense of “seeing True Reality” or a higher order reality than what is commonly available in ordinary waking consciousness. A distinct feeling that whatever is experienced as being almost “hyper-real.”
  6. 3rd Person Perspective: Psychedelics and their mind-manifesting nature can often bring about a third person perspective: a sense of looking back at yourself and your psyche as if from a detached observational position. It is this perspective that helps include the novel insights, emotions, or understandings that can arise in psychedelic experiences.

Biological Markers of Psychedelic Experiences

The psychedelic experience is largely phenomenological, or subjective. The effects are felt largely within your mind and direct experience, though with that said, there is emerging science around the neurobiology of psychedelic experiences.

Perhaps one of the most promising aspects of neurobiology impacted by psychedelic compounds is lowered activity in the Default Mode Network (DMN). The DMN is most active when you aren’t actively engaged with your external environment. It’s responsible for orientations through spatial awareness, helps provide autobiographical memory, and gives the sense of your body ending at the point of your skin —overall, it gives you the sense of being you.

With many psychedelic compounds, and in the psychedelic experience, there is a lowering of activity in the DMN, and an increased connectivity throughout the rest of the brain. Given the definition above, the sense and definition individuals have of being a single body moving through space can begin to lower as well. This is often the catalyst for the sense of “unity” or being “connected to everything” that commonly arises in the psychedelic experience. By expanding the locus of Self, individuals have the sense that they are everything around them, or that they are deeply connected to (not separate from) everything around them.

The second major neurobiological pattern that arises is a plethora of new connections being formed. In normal waking consciousness, many disparate parts of the brain may not talk to each other. Through psychedelic experiences, they may begin to connect and send signals.

This can provide the fertile ground for novel insights, experiences, and emotions. An example of this is the experience of synesthesia, or the mixing of sensory perceptions. Individuals might be able to “see” sound as a color, or taste the flavour of a painting. This is in part due to the new connections being formed.

Brain connections before and during a psilocybin session.

As more science and research is done on the nature and mechanisms of psychedelics and the psychedelic experience, you can expect to see a deeper understanding of the neurobiology of these experiences emerge as well.

The Totality of Experience

Everything listed above may sound powerful. New brain connections? Novel emotions and feelings of unity? A mystical experience beyond time? When listed out like this, these sound like a beautiful, accessible experience — why wouldn’t you want to try?

It’s important to recognize that psychedelics can provide a totality of experience. Nothing is off the table. This is an important realization when approaching this work for personal healing or growth. There are parts of yourself or patterns of behaviour that you may have hidden away, that you don’t want to look at.

Experiences like the dissolution of the individual ego, though it can grant access to a more expansive sense of Self, can also be a challenging process to go through if you have never had an experience like it before.

Psychedelics are not panaceas or “magic pills,” the work is often not easy or straightforward. Working with the experiences and fully integrating them afterwards can take some real effort. It’s important to recognize this point, and it can be an important life lesson itself: Increasing your exposure to sensitivity and positivity also increases your exposure and sensitivity to challenging emotions or experiences. All of these aspects of being are a part of you, and the psychedelic experience will often present you with the full range of the human experience.

The depth of the experience is what makes them powerful and beautiful at times. To be struck by its beauty is to come out of the fear of being alone, and to see and love yourself fully as you are right now. These are important aspects, but the path is not always an easy one to walk.

When moving forward with powerful experiences, be safe, work with trained professionals, and take the time energy to prepare adequately and integrate fully afterwards.

What if I Didn’t Have These Same Experiences?

Although the characteristic hallmarks and neurobiology of the psychedelic experience listed above are commonly understood as defining traits of the experience, this does not mean that each one happens every time.

Everyone’s experience is unique, and a timeless mantra of this work is that “you don’t get what you want, you get what you need.” For some individuals, deep emotional healing is what’s necessary, and there may be some cathartic release in the experience, rather than the mystical experience of unity with everything.

If you have had an experience that didn’t feel like this, don’t worry. Nothing went wrong, you have to trust in your body’s inner healing intelligence to deliver what you need and that it knows as well what is needed for the experience and for your healing journey.

Everyone’s experiences are different, reading someone’s story does not mean that you will have the same experience —whether the individual’s journey was positive or negative.

Your experiences can also vary from session to session, as you are a constantly growing and evolving individual. Each time you embark on a psychedelic experience you will have a different experience.

Some may be more mystical, some more emotional, others more cognitive, and potentially, others with little activity at all. This is why working with trained and experienced practitioners is important. They can help you prepare for and integrate the experiences properly, to help you reframe the experiences and weave it back into your day-to-day existence.

Conclusion

The psychedelic experience is becoming a major player in the treatment of mental health conditions. It is providing those in need of treatments, and those previously resistant to others, a path forward.

Perhaps it is specifically due to the largely ineffable nature and ability to reveal our true selves to ourselves that makes psychedelics so powerful. As more individuals are introduced to psychedelic medicine, it is helpful to have shared definitions, shared understandings, so that all individuals can make informed and effective decisions for their own healing journeys.

The therapeutic potential of ketamine can be a surprising concept to the average person outside of the medical world.

For those who are unfamiliar with its clinical application, ketamine is likely known as “Special K” or “K”, often used illegally in club and rave circles. It’s also been colloquially referred to as “horse tranquilizer” or “horse tranq”, since ketamine is primarily used as an anesthetic in humans, as well as veterinary practices.

So how did ketamine come to be known in so many different contexts?

Ketamine’s Long History of Treatment Applications in Humans

Ketamine, when used as an anesthetic in humans, puts you in a “twilight state” —a combination of pain-relieving, analgesic and memory-suppressing, amnestic qualities. That means, you’re in a state where you’re conscious, but not aware.

In medical circles, this is commonly referred to as “dissociative anesthesia”, a term coined by the wife of Dr. Edward Domino, who, along with Dr. Guenter Corssen, was the first to publish a clinical study of ketamine as a human anesthetic in 1966.

In their research of ketamine, Domino and Guenter found that in this dissociative state, patients appeared to be conscious, based on preserved airway reflexes and respiratory drive, but weren’t unable to respond to sensory input.

Zach Walsh is a PhD and professor in the department of Psychology at the University of British Columbia, whose focus is on drugs and human behavior. He explains that ketamine has a history of use as a dissociative anesthetic in humans that dates back to the 1960’s, becoming an FDA approved anesthetic medicine in the U.S. in 1970. Since then, it’s been used everywhere from battlefields to hospitals all over the world.

Ketamine’s Use in Horses and in Veterinary Practice

Despite its moniker as a “horse tranquilizer,” often with recreational and humorous overtones, ketamine is commonly used to anesthetize many species —horses and humans included— and is proven to be a safe and effective anesthetic medicine.

In large animals, such as horses, gas-based anesthetics like nitrous oxide require several parts to administer. Dosage and administration are important safety considerations when dealing with an animal weighing several hundred pounds. This is why ketamine, which can be safely administered in one injection, is often used in veterinary clinics.

The “horse tranquilizer” mythos is often conflated around this point: the medicine’s strength. The anesthetic doses of ketamine a horse would receive are much different than what a human would, based solely on size. Additionally, the use and dosage of ketamine in humans varies depending on the context it’s used —anesthetic or for mental health purposes.

In sum, is ketamine used as a horse tranquilizer? Yes, safely and in its own specific medical context. Is it fair or analogous to compare its veterinary application with its therapeutic application and healing potential in humans? Likely not.

Ketamine’s Mental Health Application in Humans

Ketamine as a treatment for mental health conditions

When ketamine is used to treat a client with mental health conditions, in lower doses, it’s felt differently. They’re still conscious and aware of what’s going on, and often able to remember some or all of the experience. This type of therapeutic application can be a powerful tool for some to break through traditional thought patterns.

“It’s an opportunity to learn and experience different ways of consciousness that might be free of whatever repetitive negative thoughts or schemas that are present during regular consciousness,” says Walsh. ”It can be helpful in that way of the subjective effects, like other psychedelics. But unlike [traditional] psychedelics, people pretty much agree that those subjective effects are key. That you have an experience and that somehow informs your subsequent consciousness and attitudes and cognitions.”

Walsh says there’s continued debate about whether or not that subjective experience is necessary.  

There is a school of thought in ketamine research that looks at its benefits mechanistically. Some researchers believe that the conscious effects are actually an artifact or even unnecessary side effect, and are focused on effects on NMDA receptors as the primary anti-depressant and anti-anxiety catalyst.

Ketamine administration and dosing basics

Clinician-prescribed ketamine is administered in different ways and dosages, depending on the context in which it’s being used. When used to treat mental conditions such as PTSD and treatment-resistant depression, it can be taken through a nasal spray, intramuscular / intravenous injection, or even a lozenge.

When ketamine is used illegally as a recreational club drug, it’s often a very low dose. When it’s used as an anesthetic, it’s administered intravenously in a higher, clinically-controlled dose.

“You wouldn’t want to be at a club if you’re taking the types of doses that are useful in [psychiatric treatment],” says Walsh.

Ketamine’s Therapeutic Benefits

What’s clear is that therapeutic use of ketamine can be effective for short term relief for severe depression. In 2019, the FDA approved esketamine, a nasal spray related to ketamine that’s used as a fast-acting antidepressant treatment. Walsh says the results are well established, and while it’s mostly used on its own, some people have used it in conjunction with traditional modalities such as psychotherapy, mental health medications like SSRI/SNRI and more invasive treatments such as electroshock therapy.

“It seems to be quite effective at relieving treatment resistant depression, at least for short periods of time,” he says.

Now, one of the challenges for those looking to develop these types of therapies is to find a way to prolong the healing effects. Walsh says the hope is combining it with an active therapeutic outlet.

“Actually engaging with that psychedelic aspect of [the experience] is something that might prolong the effects,” he says. “As it stands, it’s short acting but very effective. Especially with people who are severely suicidal, it alleviates them from that suicidal ideation.”

Walsh says some of the early research suggests that some patients using ketamine therapy can return to baseline after a couple of weeks, or sooner, depending on the severity of their condition or symptoms. Still, each experience can be really important to people who are acutely, severely depressed and suicidal.

“If you can alleviate those symptoms even for a relatively brief period then that provides a window where you might be able to make some other types of therapeutic gains,” he says.

The remarkable effects of ketamine might not be common knowledge, since progress in this arena is relatively new to the layperson. Still, it’s only a matter of time before ketamine is more widely recognized as a mental health treatment, rather than a street drug confusingly associated with horses.

Psychedelic therapy as a form of mental health treatment has yet to become mainstream, though ongoing research continues to show promising results. This is hopeful news, especially for people who have hit a wall in their efforts to treat chronic and debilitating mental health conditions.

Here are insights from four psychologists, with experience in psychedelic therapy, on why it could be the next frontier in mental health treatment.

Psychedelics Provide an Experience People Learn From

Matthew Johnson, PhD is a professor in the department of Psychiatry and Behavioral Sciences at Johns Hopkins University School of Medicine. He says psychedelic therapy is the new frontier in mental health therapy based on the results researchers have produced over the last few decades, in combination with the findings from when these compounds were researched in the 1950s and 1970s.

“The drugs biologically facilitate psychotherapeutic processes,” he explains. “They prompt an experience that people learn from and that learning has long term, behavioural impact. That’s fundamentally different from the treatment of surface level symptoms that you see with virtually all other psychiatric medications. Most psychiatric medications treat the symptoms, they don’t treat the core of the illness.”

The core of the illness is typically psychological in nature, Johnson says.

For example, the medications that treat addiction, which are approved by the FDA, by and large work by interacting with the receptor system in the brain that mediates the rewarding properties, the craving, and the withdrawal you get from that drug. This is treating symptoms but the nature of addiction is not simply the withdrawal state. It’s far more than that.

“You name the drug, there’s a lot of people who’ve gotten past the withdrawal and relapsed,” Johnson says. “It’s a deeper seeded psychological issue. With psychedelics, they prompt experiences which people learn from, which is the goal of psychotherapy. But it’s often not that powerful. Psychedelics biologically enhance what’s possible with psychotherapy.”

Johnson admits there’s still a lot of groundwork to do when it comes to regulating psychedelic therapy. A big component of that is the Risk Evaluation Mitigation Strategies (REMS) program required by the FDA.

“You need people trained in treatment,” he says. “There’s a whole number of factors that are going to need to be worked on…There’d need to be new clinics. What needs to be figured out is how to keep clinicians on the rails without delving into or adopting the role of priest or shaman, which is a danger in this area. There’s a whole field of professional development that needs to come along.”

While psychedelic therapy might not be for everyone, Johnson says the data holds up that it could help a lot of people. But it’s crucial that they be used in the right way that mitigates the risks.

Psychedelics Provide Another Access Point for Behavioral Change

Norman Farb, PhD of Psychology is an associate professor at the University of Toronto and the director of the school’s psychedelics studies research program. He explains that psychedelic therapy accesses another door into human behavior, revealing the deeply automated patterns of the mind.

“There’s lots of schools of thoughts on how you can give people insight or access to noticing those habits and potentially to work with what they notice,” he says. “From my perspective, psychedelics provide another one of those access points. You can have diary entries, meditation, you can talk it out with people, you can do dream analysis. Psychedelics is potentially another tool in that toolkit to help reveal the deeply automated patterns of the mind.”

This type of treatment isn’t anything new, Farb explains, as cultures have been using psychedelics for thousands of years. Now that there’s interest in its potential to treat mental illnesses, there’s commercial interest in what the next big antidepressant or antianxiety drug will be, especially since there hasn’t been much movement in that area for years.

Farb believes there can be a lot of benefits from psychedelic therapy if used in the right way, especially for people who aren’t particularly introspective on their own.

“It’s a way to fast track into having some insights,” he says. “There’s probably a lot of reason why people either automate or condition themselves to avoid having access to some of these experiences and there’s a lot of learning that will have to be done on the therapist’s side to live up to the promise of providing safe, introspective experiences that lead to some sort of positive transformation or insight or growth.”

Farb says his optimism around the use of psychedelics as psychotherapy is “guarded.”

“Once you get someone to be open to new ideas and new perspectives on things and you work on testing some of those ideas and looking at the functional outcomes of relating to other people…that is the therapeutic arch. [Psychotherapists] can definitely empower that arch. But the drugs aren’t going to do that work.”

Mental Discomfort is Rising, Psychedelic Therapy Could Help

Dr. Gabor Maté is an internationally renowned expert on addiction and mental illness. In an interview with YouTube channel Rebel Wisdom, Maté explained why psychedelic therapy could have potential, based on the prevalence of mental illness in society and the lack of treatment options that makes a lasting difference.

“Why are we even looking at psychedelics? For two reasons. Mental illness is burgeoning in society, anxiety is the fastest growing diagnosis on both sides of the Atlantic and more and more people are depressed…for social reasons, mental discomfort is rising,” he says.

“Number two, there’s the largely complete failure of the Western medical system, of which I was trained and practiced, to deal with the crisis of mental health. We don’t understand it. Fundamentally we’re in denial about the unity of the human soul and the mind and the body. We’re in denial about the social nature of human beings, we look upon mental illness as [solely] biological problems. So people are looking for solutions beyond the mainstream as they have to, because even within the mainstream the responses and the preventions are so inadequate.”

Psychedelic Therapy Goes After the Root Causes of Problems

Rick Doblin, PhD is the founder and executive director of the Multidisciplinary Association for Psychedelic Studies (MAPS). In a 2019 TED Talk, he speaks on how we’re experiencing a global renaissance of psychedelic research.

“Psychedelic psychotherapy is showing great promise for the treatment of post-traumatic stress disorder, or PTSD, depression, social anxiety, substance abuse and alcoholism and suicide,” he says.

“Psychedelic psychotherapy is an attempt to go after the root causes of the problems, with just relatively few administrations, as contrasted to most of the psychiatric drugs used today that are mostly just reducing symptoms and are meant to be taken on a daily basis. Psychedelics are now also being used as tools for neuroscience to study brain function and to study the enduring mystery of human consciousness. And psychedelics and the mystical experiences they produce are being explored for their connections between meditation and mindfulness.”

Psychedelic and ketamine therapy are becoming common topics in common culture and public parlance more and more each day. For good reason, continued research and clinical studies show positive results when these medicines and compounds are used to treat a variety of mental health conditions. 

Combined with the existing safety and efficacy profiles of ketamine, and the supportive reports of clients who have completed ketamine treatment, it’s easy to herald these experiences, programs, and medicines as “wonder drugs.” 

This is compounded when legendary figures in the space such as Stanislov Grof, responsible for thousands of early studies on LSD psychotherapy, submit claims like “…psychedelics, used responsibly and with proper caution, would be for psychiatry what the microscope is for biology and medicine or the telescope is for astronomy.” 

These are big, bold statements, and there are solid arguments in support of this across academic research, clinical studies, and real client experiences. However, it’s easy for ketamine and other psychedelic medicines to develop a sort of “halo effect” as a magic pill that can cure whatever is ailing you. All you need to do is show up and take it, right?

This “magic pill” moniker has its downsides. It diminishes the importance of ”Set and Setting” and adequate experience, preparation and integration, and overstates the long-lasting impact of the psychological benefits that ketamine and psychedelic medicines can and do provide. 

All of the additional components of safe and effective psychedelic therapy —the clinicians/practitioners, the therapeutic containers they are taken within, the ongoing individual evolution of personal narratives and challenging habit change— can be just as significant to realizing powerful results and experiences in individual sessions and throughout the entire programmatic arcs of these experiences.

Defining the “Magic Pill”

At a first look, it’s easy to derive the essence of what is meant when someone says that ketamine, psychedelic medicine, and psychedelic therapy is a “magic pill.”

Given that the method of administration for many of these compounds is in a pill or other easily ingestible form, it’s easy to make the assumption that all an individual needs to do is show up, take a psychedelic medicine, and be magically cured of existing ailments.  

Psychedelic medicine is being explored as a treatment everything from treatment-resistant depression, to major anxiety challenges, OCD, substance abuse problems, and a host of other mental health conditions. Since traditional treatment modalities typically require months to years to see improvements, psychedelic medicines can seem like a “magic pill” treatment in comparison.

It is true that there are impressive and substantiated results throughout the clinical and therapeutic worlds of the profound potential and promise of psychedelic medicines. However, the myopic view of narrowing down psychedelic therapy to solely the physiological effects of ingesting psychedelic medicines can do more harm than good to individual clients. This view also can negatively affect the emergence of psychedelic medicine as a whole as it moves into maturity.

As with anything that is oversimplified, this “magic pill” designation leaves out important nuances, steps of the process, and the small refinements that are critical and necessary components in helping clients heal, integrate, and enjoy powerful experiences in the sessions and throughout the program. 

What Gets Left Out of the “Magic Pill” Conversation

There are many essential components of any reputable psychedelic therapy protocol that are left out in the definition of psychedelic medicines as “magic pills”. 

Some critical aspects of the experience include:

Trained practitioners 

Working alongside trained and licensed practitioners/clinicians throughout the psychedelic therapy process is an essential factor in the results that a client may realize throughout the process. Practitioners and clinicians facilitate the initial intake ensuring client safety, titrate or adjust doses effectively,  and help explore the results and begin the integration process.

Preparation and intention

Preparing the individual’s mindset and physical space they will have their experience in (also referred to as ”Set & Setting”), as well as clearly defining personal intentions for embarking on these experiences, have a massive influence in the experience an individual has. This is entirely antithetical to the notion of the magic pill as something you just “show up and take.” 

Processing and Understanding Experiences

It is possible that many dormant or novel emotions, insights, and experiences may arise throughout a psychedelic therapy session. It is not a given that it will be immediately understandable and actionable by a client once they have completed the session. The purpose or importance of some of these insights/experience may not be obvious until they have been carefully unpacked in the integration process, or with the assistance of the practitioner and/or licensed therapist. 

Although there can be significant experiences that have immediate and long-lasting effects on the individuals, this is not always the case. Presenting psychedelic medicine experiences as if no additional processing work is necessary afterwards —that an individual just emerges from an experience “:completely changed for the better, forever”— is simply not true. Giving clients this expectation going into the experience can make the reverberations more difficult or strenuous.

Ongoing Integration

Building off the last point, there may be a significant integration process afterwards, as the individual begins to take the lessons and emotions  from the medicine session and enact and embody them in their life back at home. This process can take days, weeks, months, or years to fully realize, and some lessons or next steps may not have clearly defined end dates at all. 

Though there can be significant and powerful healing done immediately within the sessions, as one would hope for the individual, the reality is that enduring and significant personal change from psychedelic therapy often has a long-tail of integration work that accompanies it. This should be known and communicated to clients before they undergo an experience, so that they are clearly aware that the medicine experiences themselves are but the first step on an ongoing journey of healing and wholeness.

Ketamine’s Role in Healing

Given a complete overview of all the necessary components that contribute to powerful and long-lasting results throughout ketamine treatment and psychedelic therapy experiences, does this mean that there are no significant results that can come about in the experiences themselves? 

Not at all.

There are significant psychological and neurological changes that occur during the experiences as a direct result of taking the medicine. These are important drivers of the outcomes that have been realized by clients and the psychedelic medicine studies that have been conducted, and are currently ongoing.

With ketamine in particular, there are a host of beneficial changes that occur in the brain and mood that are helpful in the treatment of certain mental health conditions, and that also make the ongoing integration afterwards more powerful. 

Some of these neurological and psychological benefits of ketamine include:

Increased neuroplasticity 

By increasing the levels of BDNF (brain-derived neurotrophic factor) in the brain through the ingestion of ketamine and some other psychedelic medicines, the brain moves into a more flexible state for the following 3-14 days. This means that new patterns of thought are possible, it can become easier to pick up new habits and behaviors, and embedding new ways of thinking and acting can come easier to an individual. This is incredibly supportive of the integration work to come.

Increased mood regulation 

Clinicians would hope to also see a baseline increase in overall mood and demeanor in the days that follow. A more positive outlook and average emotional state can provide great motivation and reprieve for individuals working with anxiety or depression, perhaps granting them access to emotional states that have been hidden away for some time. There is also a complimentary increase in the ability to regulate moods and emotions, making difficult conversations or major tasks more accessible, which can be critical in realizing long-term, sustained changes. 

New emotions and insights 

There may be the direct experience of new or hidden emotions/insights/experiences that arise throughout an experience that can have significant impacts just from the direct experience itself. Experiences of connection, emotions like joy, or insights around certain patterns of behavior, can be significant catalysts for an individual and can endure for a significant time afterwards.

Improving brain health

Particularly in the case of ketamine treatment, improved levels of mTOR and GABA contribute to increasing the health of the brain’s synapses and neural connections. These areas of the brain can be damaged due to prolonged stress or depression. Improving brain health contributes to cognition, mood regulation, and the ability to enact behavioral change in the long-term. 

These are a few examples of the immediate effects of psychedelic medicines and ketamine that contribute in no small way to the powerful experiences and important results clients see in psychedelic therapy programs.

The Reality of Psychedelic Therapy

As with much of the work and results in the psychedelic therapy world, the reality of these medicines as “magic pills” isn’t so much ‘either/or’, but ‘both/and’. They are both incredibly powerful and beneficial experiences, and they are made that way through a much more comprehensive experiential arc than just the medicine experiences themselves.

There are significant and important components of the preparation, processing, and integration factors that contribute to the results that clients see, and there are significant and important experiences that arise within the sessions, or come about as a by-product of taking the medicines themselves. 

It is by embracing a more holistic view of psychedelic therapy and ketamine treatment that the full power and potential of these experiences are unlocked. Yes, there are incredible results that arise through this work where other combinations of psychotherapy and pharmacology have been unable to. Some examples are enduring smoking-cessation brought about by a single psilocybin session, or in helping an individual heal treatment-resistant depression, These results are real and promising, but they are results that were achieved through the entirety of the psychedelic therapy structure and experience, not simply the medicine experiences themselves.

The Greatest Benefits Are Achieved Through Holistic Treatment

Psychedelic medicines are not magic pills, but the results that psychedelic therapy programs are achieving for clients is remarkable and worth paying attention to. Research being done continues to support the validity of these claims.

There must be a cautious optimism applied in these discussions, to give credence to both the medicine and the programs, and who these experiences are suitable for and who they aren’t. 

With all parties and stakeholders involved taking this more holistic view, the psychedelic medicine world can continue to refine and improve, providing greater healing for clients and replicable, effective protocols for the practitioners and organizations facilitating these experiences.

Any good faith and informed exploration of ketamine and ketamine treatment should include a list of potential side effects that a client may experience. There are both neurobiological and phenomenological side effects that may arise in the short-term immediately after a session, or longer-term through persistent use.

It’s important for practitioners, clinicians, and clients working with this medicine to be informed of these potential side effects, and their frequency and severity. This helps to make informed decisions about moving forward with ketamine treatment and psychedelic therapy programs.

Ketamine is a medication used for a variety of purposes including anesthesia during surgery, pain relief (analgesia), and treatment of mental health concerns, meaning it has the ability to act on multiple areas of the body. When used to treat mental health conditions, it is acting on the brain.

However, during these treatments, ketamine impacts other physiological functions as well. This can result in objective and subjective side effects, even with a single treatment. These effects are sometimes referred to as “body load,” or physical sensations brought on by the ketamine and other similar substances which may be difficult to describe. This article will explore both of these categories of side effects from both a short-term and long-term perspective. Let’s begin by defining what the term “side effect” means.

Defining “Side Effects”

In medical terms, the term “side effect” is used to describe an unwanted or unintended effect of a drug. Although the term is predominantly used to describe adverse effects (mild, moderate, to severe), there are some side effects that can be beneficial.

Using this definition, you can say that the antidepressant and anxiolytic properties are a beneficial side effect of ketamine since its initial intended use was as a surgical anesthetic. Using this example, we can see that not all side effects are negative. However, this article will address the adverse side effects possible from consuming ketamine.

If you would like to explore the positive and beneficial aspects of ketamine treatment for mental health, check out our resources addressing anxiety, depression, and treatment-resistant depression directly.

Side effects can differ in severity, duration, and manner of effect — neurobiological and psychological. Some side effects are simply minor developments that fade quickly after a session, while less common but more severe side effects may require additional attention or care.

Clinical Administration vs. Recreational Use: A Distinction

Before exploring the neurobiological and psychological side effects in more detail, it is important to draw a critical distinction between the method of administration and how this relates to side effect development and prevalence. Namely, the context in which the client is receiving ketamine.

Most of the literature surrounding the side effects of ketamine looks at these effects under the context of habitual recreational use with or without addictive behavior patterns present. These are side effects that can arise from frequent use of unknown quantities, perhaps with increasing amounts of ketamine, for a sustained period of time.

When medications are taken in a manner, dose, or environment other than what is prescribed by a clinician, the potential for adverse side effects increases, as can the severity of side effects.

When working with ketamine, doing so in a structured treatment program alongside trained and experienced clinicians is of the utmost importance. The included protocols are set up to protect client safety, and ensure individuals have the support, care, and guidance that is necessary to work effectively with these medicine experiences.

Side effects are still present in clinical and therapeutic contexts, but the structured support environment is more conducive to modify the treatment plan should side effects arise, if continued therapeutic work is recommended.

If you are currently working within a ketamine treatment protocol or psychedelic therapy program, it is important to inform your care team of any concerns, questions, or comments you have surrounding your experience and the emergence of anything you may consider an adverse side effect. You have a team there to support you, and it’s beneficial to work with their domain expertise and experience throughout these programs.

Short-Term Neurobiological Side Effects

Beginning with the neurobiological side effects of ketamine, there are a number of side effects that may emerge during a treatment session, or in the few hours after a session.

Since ketamine acts on the nervous system as a whole, it is important to block off sufficient time after treatments to allow for recovery. It’s recommended to give your body the space and time it requires to process and metabolize the medicine.

Some short-term neurobiological side effects of ketamine may include:

  • Elevated blood pressure and increased heart rate
  • Nausea, occasionally with vomiting
  • Drowsiness
  • Disorientation and confusion
  • Headache

There are steps involved in the preparation and post-session suggestions to help manage and mitigate the potential of these side effects as much as possible.

For example, the dissolvable sublingual tablets used in Mindbloom’s treatment protocol are not meant to be swallowed, nor the saliva that they dissolve into. Swallowing the dissolved tablets and saliva greatly increases the potential for neurobiological side effects, which may include increased drowsiness, dizziness, and/or nausea.

Knowing this information is half the battle. If you are aware of the potential for these side effects to emerge, it is much easier to prepare beforehand and be ready for them if they do emerge. Rest and stillness are helpful in dealing with many common short-term neurobiological side effects that do emerge.

As the experience will be unique for each client, it’s important to be informed of side effects beforehand. Equally important is having someone to support and watch out for you during and after the session, and having plans in place that were coordinated with the assistance of a clinical care team to remedy these effects if they do arise. Some individuals may experience multiple side effects, while others may experience few or none at all.

If you have any concerns about this, or feel like you want extra support in the sessions, open this dialogue with your clinical care team so that you feel safe and supported going into the treatment session — an important feature to create safe and powerful experiences.

Long-Term Neurobiological Side Effects

As mentioned before, if you are working with a professional clinical care team, the treatment protocols, including specific session dosages, and frequency of your sessions will help to avoid any long-term adverse side effects.

The side effects listed below have emerged largely in the context of frequent habitual recreational use, with or without associated addictive patterns and behaviors. Ketamine does impact the body, particularly the kidneys, and it is important to be aware of this beforehand.

Some potential long-term physiological side effects of ketamine use include:

  • Kidney injury or damage
  • Trouble or pain with urinating
  • Substance dependence and tolerance
  • Baseline increase in heart rate
  • Baseline increase in blood pressure
  • Respiratory depression
  • Possibility of seizures

Given the potential side effects of long-term ketamine use, it is important to follow the prescriptions and protocols of your treatment program, as these are developed and prescribed to safely avoid these long-term effects while still providing effective and therapeutic experiences.

If any concerns or questions emerge throughout your course of treatment, please check in with your care team to go over these in detail. Treatment feedback is important and allows your clinical care team to make informed and safe decisions regarding your program.

Short-Term Psychological Side Effects

Ketamine can also have psychological side effects —those that emerge at the level of emotions, thought patterns, and waking conscious state.

There are both short-term and long-term experiential side effects that may occur as well. Both working with trained professionals in a safe context, and adequate preparation of set and setting help to manage and mitigate the emergence or the severity of potential side effects.

Some short-term psychological side effects that can arise during or just after a treatment session may include:

  • Stress from processing emotions/memories
  • Disconnection from existing life
  • Anxiety, depression, or worsening of these
  • Increase in irritability/fragility

As a consciousness-altering agent, ketamine treatment can have a profound and important impact on your mental health. However, if not managed safely and effectively, these experiences can also surface unintended consequences.

If you have a significant emotional experience in the session, it may take some time outside of the planned treatment time to process fully.. This may cause some short-term emotional stress. Experiences that are new to you may occur: out-of-body moments, visual or auditory hallucinations, or disconnection from thoughts and the body. This can be alarming for some.

As you process the experiential information, there may be periods of emotional lability or confusion. If this does happen, work with your support systems, take time to rest, and allow the medicine to metabolize fully. The effects should decrease and resolve as the medication is broken down and exits the body.

Long-Term Psychological Side Effects

Continued or frequent use of ketamine can lead to long-term changes to your brain, resulting in altered cognitive abilities and mental health.

Again, research suggests that these side effects are predominantly seen in the content of chronic recreational use with or without addictive behaviors present, and can be mitigated and managed by working with your clinical care team and taking the medication as prescribed.

Some potential long-term psychological side effects may include:

  • Degraded memory recall/storage
  • Lowered subjective sense of wellbeing
  • Changes in sleep habits

Following the treatment protocols of an experienced clinician should prevent long-term side effects like those mentioned above from occurring. This is because your clinician will likely require periodic appointments to check for efficacy of treatment and possible side effects that you may be experiencing before prescribing more Ketamine.

Having an informed understanding of the medicine, of the potential therapeutic benefits and adverse side effects that exist, and working within your therapeutic container, will all serve to provide safe, effective, and powerful experiences.

How to Manage/Mitigate Potential Side Effects

Like any medicine, ketamine comes with its own associated neurobiological and psychological side effects, some of them healing and welcome, some of them potentially distressing and adverse.

Fortunately, ketamine has been researched for several decades, initially gaining FDA approval in 1970 as a fast-acting anesthetic. Since then it’s uses as an analgesic and its mental health benefits have been studied in depth. It is currently the most well-studied psychedelic medicine available for prescription by a clinician. From these studies a number of best-practices and safety protocols have emerged.

If you have any concerns about the potential side effects that can arise, here are a few steps you can take to help mitigate or manage these:

  1. Talk to Your Clinician: This is always the first step. If you have any concerns or questions, bring this up with your clinical care team so that all parties are informed. This is not something you have to, nor should you, figure out and manage by yourself. You have a care team supporting you through these experiences, your safety and addressing side effects is one of the things they are here to help with.
  2. Follow the Program Protocols: All of the recommendations, requirements, and procedures that are part of your treatment protocol are there for a reason. Nothing is redundant. Requirements such as not eating a few hours beforehand, having a peer monitor present throughout the experience, and recommendations like preparing yourself physically and mentally beforehand, and setting clear intentions are in place to help provide safe, effective, and powerful healing experiences. Follow the recommendations that your care team provides.
  3. Set & Setting: Preparation is important, particularly for powerful healing experiences like these. Taking the time to prepare beforehand, ensuring that you are in an open and welcoming mental space. Make sure that your physical environment is set up to be comfortable and supportive, that you have clear intentions, and are in a state of trust and openness. These all help the process, ensuring you can manage any physical side effects and are well-equipped to handle any side effects that may arise in the sessions.
  4. Take Care of Your Health: There is a lot that you can do outside of the sessions themselves to help mitigate or manage the impact potential of side effects. Take care of your physical health in all areas, and welcome and explore your emotions. The more grounded and fit your mind and body are coming in, the more you can receive the medicine and welcome anything that wishes to arise throughout the program.
  5. Trust, Let Go, Be Open: A timeless mantra in the psychedelic therapy world, trust that the experience will bring you what you need. Let go of your expectations or requirements for the sessions, and be open to the nature of the experience and to the way the medicine is experienced.

Following These Steps Will Help You Fully Prepare

These steps are not bulletproof guarantees that in following them you will not experience any potential side effects. These steps help you to fully prepare as best as possible, so that you have resources available to you if any of these do begin to arise during or after the dosing sessions.

Work with your team, work with yourself, follow the recommended guidelines, and you will be more likely to have the safe, effective, and powerful experiences that you embarked on this healing journey for.

Expanding access to at-home ketamine therapy is one of Mindbloom’s core objectives, which we’re achieving by making access to treatment more approachable, affordable, and available.

Today, we’re proud to announce a big milestone in treatment availability: 50% coverage of the U.S. population.

You now have access to a team of licensed psychiatric clinicians, and dedicated Mindbloom Guides, who will provide personalized, transformational treatment experiences in the comfort and safety of your own home. This means no long drives to in-person appointments, no cramped waiting rooms, and no providers who have limited mental healthcare experience.

The level of care we provide speaks for itself: Over 90% of Mindbloom clients report improvement in anxiety or depression symptoms following Mindbloom treatment.

If you —or anyone you know— may benefit from working with Mindbloom, take our brief assessment to see if you’re a candidate.

For future coverage and Mindbloom announcements, follow us on Instagram and check back here on our blog for more details.

Want to be a part of our mission to expand access to these transformational client experiences? Join our team of mission-obsessed clinicians, guides, and technologists, who are building a unique company Culture of Consciousness.

So you’ve made the decision to embark on a psychedelic therapy program… what now?

How do you adequately prepare yourself and your environment to be as conducive and helpful as possible to the process?

There are many terms that may be new or unfamiliar as you embark on this adventure of healing and wholeness: intentions, Set and Setting, dosages, subjective effects, and more. This list is long, and getting into the right relationship with the preparation process is an important undertaking worthy of your consideration.

This article makes the assumption that you have already selected a medicine and program to work with, have begun the program, and have been paired with a practitioner or clinician. The focus of this resource is to discuss the space between your initial registration for the program/experience and the first session of the program.

Update Your Clinician on Health Changes

An important start to the preparatory process is notifying your clinician/practitioner of any major changes to your physical and mental health throughout this process.

As there are certain contraindications —reasons to withhold treatment— for each medicine and experience. Changes outside of healthy ranges for factors like blood pressure or heart rate, or any changes to your physical or mental health should be relayed to your clinician as soon as you have this information. It is important that they have complete information so that you remain safe, and that the experiences are healing and help you realize the outcomes that you agree on.

Examples of some changes to report can be:

  • Major increases in anxiety or depression levels
  • Suicidal ideation or suicidal attempts
  • Newly discovered family health history information (ie: history of bi-polar)
  • New clinical diagnoses of physical or mental health conditions
  • Major shifts in resting heart rate or blood pressure levels
  • Newly prescribed medications (including changes in dosages)
  • Newly pregnant or possibility of pregnancy

Your health and safety are the number one priority in any psychedelic therapy program. Your clinician/practitioner will make key decisions such as your eligibility for the treatment entirely, the medication dosage, level of additional support required, and other factors.

For these reasons, it is essential and imperative that they have a complete picture to begin the program, and remain informed of any changes as they unfold before, during, and after the experiences and throughout the entire therapeutic program.

Ask “Why Am I Choosing This Path?”

Before diving in, getting clear on your “why” is also important.

Why are you doing this? What is going on in your life and your inner world that has called you to embark on this healing journey?

Sometimes you are brought to things that your inner healing intelligence knows are the next step, without full conscious clarity as to why.

Being clear on why you are doing this, what the aims and aspirations are, in clear conscious communication, is an important first step. Set aside some time with yourself, perhaps talking to a loved one, writing in a journal, or just speaking out loud “Why am I doing this?

The helpful step is going through the earnest attempt to put it into linear language. Intentions, motivations, and internal drives that live swirling around in your head as impulses, images, disparate words, or memories can be vague and unclear.

Take the time, and make the initial investment in this entire process, to unpack and put into language your “why” is an important first step. If you feel like you can use some assistance with this process, this is also something that your clinician or practitioner can help with early on in your intake process.

Consider Your Set and Setting

“Set and Setting” emerged as a cornerstone concept in early clinical trials in psychedelic science throughout the 1950’s and 60’s. This concept has had a profound influence on the power and experiential journey in psychedelic experiences to date.

“Set” Explained

Set refers to your individual mindset going into the experience. It is helpful to approach your first session in a calm, trusting, and open mindset. As an example, a less than conducive mindset may include things like feeling hectic from a busy day beforehand, extreme doubt or fear of the experience, or being angry or upset about other areas of life.

Taking the time to prepare your mindset in the days and hours leading up to an experience helps create the most favorable conditions for powerful experiences and positive outcomes.

Mindset preparation steps include:

  • Getting restful sleep the night before
  • Taking time to journal and feel relaxed and composed
  • Resolving any questions beforehand to feel informed and trusting
  • Meditating or walking beforehand to feel calm yet alert throughout the experience

“Setting” Explained

Setting on the other hand, refers to the physical environment that you will have the experience in. This may be the office of a clinician/practitioner, or in the comfort of your own home. Having a welcome, safe, quiet, and uninterrupted environment will once again help to create the most conducive conditions for a safe and powerful experience.

Setting preparation steps include:

  • Dimming the lights to turn your focus inward
  • Cleaning up the room, putting things in their place, and ensuring there is a clear, unobstructed path to the washroom
  • Asking any roommates to kindly refrain from entering the room before, during, and just after the experience (unless they are required to do as a Peer Monitor, in which case just asking them to remain quiet when doing so)
  • Keeping any pets or children out of the room during the experience
  • Wearing comfortable, loose-fitting clothing
  • Adding your own comforting touches, such as an eye mask, calming scents, any sentimental or important items that help create a calm, open environment

It is very easy to underestimate the importance of Set and Setting and the influence they have on the safety, efficacy, and outcomes you experience during psychedelic therapy. Just a few minutes of preparing your mindset and physical setting contribute greatly to the overall experience you have.

You will likely receive some Set and Setting recommendations from your clinician/practitioner. If you don’t, it is worthwhile to inquire about this beforehand. If none are provided, the recommendations above will help this preparation process.

Set Your Intentions

Intentions are a cornerstone of the psychedelic experience, and an essential component of the process of preparing for your sessions.

An intention is a simple statement that articulates the way you would like to show up for the session, the themes in your life you would like to address, or states of being you wish to embody.

An important point is that an intention is fundamentally different from an expectation. An expectation can be perceived as a requirement, and you may spend the session time waiting for your expectation to arise and come to pass. The experiences will unfold naturally, in conjunction with your internal states and your inner healing intelligence. Though we cannot dictate the experience, we can meet it halfway, in open dialogue. This is the role of an intention. Learn more about setting intentions and read examples in this resource.

Intentions are highly personal, and they vary also from session to session. Your intention for one session may be entirely different for the next one. Each experience is unique, and so each intention should be as well.

It is helpful to spend some time working on your intention in private, but you can, and should, work to clarify and refine with your clinician/practitioner before embarking on your experience.

Learn to “Clear House”

If you are prone to rumination or distracting thoughts, it can be helpful to take some time to “clear house” before embarking on your psychedelic therapy program/experience.

This means taking a bit of time to tackle any outstanding tasks that have been slipping. It can literally be taking the time to clean up your living space. It might be addressing a few dusty tasks on the to-do list, like giving friends or family a call or check-in. The sooner you can address things that might catch your attention during the experience, the more you arrive in full presence for the experience you are about to have.

If you don’t have the available time, energy, or resources to take care of everything, or if some tasks are much larger undertakings, there is no need to stress about this. This is just a caring suggestion in case you are looking for additional ways to prepare for your experience.

For example, if you have recently had a disagreement or argument with somebody, or if there is something left unsaid that continues to arise in your awareness, taking some steps to resolve this beforehand can be very helpful. You’ll notice that taking care of these minor “clearing house” tasks go towards preparing a more conducive Set and Setting.

Trust, Let Go, and Be Open

“Trust, Let Go, and Be Open” (or TLO) is a time-tested mantra developed through ongoing work in psychedelic science, and the early clinical research done during the advent of psychedelic medicine.

Early clients faced the same concerns, fears of the unknown, and anticipatory excitement that arises in the weeks and days before embarking on a psychedelic therapy program. Through continued refinement and establishment of best practices, TLO came about as a useful framing to help prepare yourself for your experiences.

Trust

Trust comes first. Trust that the experience(s) you will have will contribute to your healing and surface any relevant emotions or insights to help you on your way. Trust that you are safe, working with appropriate dosages, and that you’ve enlisted the help of skilled and experienced practitioners. Trust in your inner healing intelligence to be serving you and active during your process. Trust in yourself as being ready and able to move forward in your journey of healing and wholeness.

Let Go

Letting go helps us fully arrive and be present with the experience as it unfolds for us. Holding on to preconceived notions of what the experience will be like, or gripping tightly to expectations of what we require, can hinder progress or make certain experiences more difficult than they need to be. If you are already trusting, you can let go of ideas, concerns, and expectations, and receive the experience exactly as it wants to appear for you.

Be Open

Once you have let go of the particular requirements or ideas you may have, you are able to fully be open to the experience. Be open to the possibility that you can realize your intentions for this program. Be open to the idea that you can heal and move towards wholeness. Be open to the understanding that the experiences and emotions are arising for a reason, and that through the integration process you will be able to recognize important insights and bring these into a new way of being for yourself.

With your “why” clearly defined, Set and Setting ready, intentions set, and TLO at the front of your mind, you are more than ready to embark on your healing experience in psychedelic therapy. These preparatory steps will serve you well, and though the experience may not go as you plan, it will always deliver what you need. Experiences can be intense, they can also be mild. They can be clear and direct, they can also be vague and nebulous.

Preparing for psychedelic therapy will help provide the best possible conditions for your experience, but the experience will always emerge as wants. Doing your due diligence to prepare is a helpful part of the process, and most importantly, it is the one aspect that is in your control. An important first step of showing up fully for psychedelic therapy is to show up fully for the preparatory process.

Enjoy the Process!

A final note is to enjoy this process. It is a great honor, privilege, and opportunity to be able to do this work for yourself. To have the means, energy, and resources available to continue your journey of healing and wholeness with psychedelic therapy.

Though the healing process can feel like hard work at times, and there will most certainly be challenging moments, it’s important to enjoy this process. To take pride in showing up for yourself in this way, and to express gratitude for this level of self-love and self-acceptance that you are showing yourself. It is a beautiful gift to give yourself, so enjoy the process and recognize yourself for choosing this journey.